Clinical Research Directory

Inclusion Criteria: * Informed Consent as documented by signature * Peri- and postmenopausal woman * Indication for MHT (e.g. climacteric syndrome, osteoporosis, etc.) * Age ≥ 18 years * German Speaking Exclusion Criteria: * Obesity BMI ≥ 30 kg/m² * Pregnancy or Lactation * Status post Hysterectomy * Systemic hormone therapy or hormonal contraception (estrogens, progestogens, androgens) during the study and within 12 weeks prior to study entry * Prescribed medication for therapy of sleep problems 12 weeks prior to study entry (excluding phytotherapeutic agents and over the counter medication) * Medication that could distort sleep (e.g. antidepressant, anticonvulsant and antipsychotic medications) * Substance abuse (e.g. daily alcohol consumption, drugs in general) * Contraindication for menopausal hormone therapy according to swissmedicinfo.ch * Neoplasia of the breast or other sexual organ * Benign or malignant liver tumors * Acute or chronic liver disease * Cholestatic jaundice * Porphyria * Arterial or venous thromboembolic events * Abnormal genital bleeding of unknown cause * Known or suspected non-compliance due to inability to follow the procedures of the study (e.g. illiteracy, language problems, psychological disorders, dementia, etc.)