Clinical Research Directory

Inclusion Criteria: * Patients with acute or chronic coronary syndromes referred for invasive coronary angiography with clinically indicated coronary physiologic assessment. In patients with acute coronary syndromes, the physiological evaluation will be restricted to non-culprit vessels. * Patients with intermediate CAD (30-90% visual stenosis) with clinically indicated FFR assessment. * Patients with NOCAD (\<30% visual stenosis) with clinically indicated microvascular assessment. Exclusion Criteria: * Patients presenting with ST-elevation * Prior myocardial infarction in the target vessel * Stent implantation in the target vessel within the last 12 months * Previous coronary artery bypass grafting surgery (CABG) * Previous heart valve surgery * Previous heart transplantation * Moderate-to-severe valvular disease * Left ventricular ejection fraction (EF) ≤45% * Hemodynamic instability or cardiogenic shock Angiographic Exclusion Criteria * Left main stenosis≥50% * Chronic total occlusion in the target vessel * CTO in a non-target vessel * Less than thrombolysis in myocardial infarction (TIMI) 3 flow in the target vessel * Target vessel receiving collaterals * Inadequate coronary angiographic images * Ostial lesions * Severe tortuosity