Clinical Research Directory

Inclusion Criteria: * Female aged ≥18 years. * Histologically confirmed metastatic breast carcinoma, regardless of histological subtype, hormone receptor status, HER2 status, or tumor grade. * Receiving systemic anticancer treatment for metastatic breast cancer, including chemotherapy, immunotherapy, endocrine therapy, targeted therapy, or combination regimens. * Clinical response or stable disease according to RECIST v1.1 on the most recent imaging assessment performed within 3 months before enrollment, except for the primary breast lesion, which may be progressing. * Eligible for cryoablation of the primary breast tumor: * ECOG Performance Status ≤2. * Effective contraception for women of childbearing potential. * Able and willing to provide written informed consent. Exclusion Criteria: * Contraindication to cryoablation according to the investigator and/or interventional radiologist. * Contraindication to gadolinium-enhanced breast MRI according to institutional practice and radiologist assessment. * Pregnant or breastfeeding women. * Participation in another interventional clinical study with an ongoing exclusion period or that could interfere with the present study according to investigator judgment. * Psychiatric disorder or any medical condition that, in the opinion of the investigator, could compromise study participation or compliance with study procedures. * Adults under legal protection or unable to provide informed consent. * Persons deprived of liberty by judicial or administrative decision. * Absence of health insurance coverage.