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Ralation Between Cardiorespiratory Fitness and Mean Corrected Intraocular Pressure
Sponsor: Sichuan Academy of Medical Sciences
Summary
Objective: To investigate the association between cardiorespiratory fitness and mean corrected intraocular pressure (IOP) in a normotensive health check-up population, and to evaluate potential differences across age and sex strata. Methods: This cross-sectional study consecutively enrolled adults aged 18-70 years who completed cardiorespiratory fitness testing and ophthalmologic examinations at the Health Management Center of Sichuan Provincial People's Hospital between July 1, 2019 and December 31, 2025. Individuals were excluded if they had a history of glaucoma, ocular diseases interfering with IOP measurement, systemic diseases or medications affecting IOP, contraindications to fitness testing, or abnormal blood pressure. A final sample of 2,921 normotensive individuals was included. Cardiorespiratory fitness was assessed by estimated maximal oxygen uptake (VO₂max). After age- and sex-stratified grouping, low cardiorespiratory fitness was used as the reference, and the remainder were defined as the moderate-to-high cardiorespiratory fitness group. The primary outcome was the mean corrected IOP of both eyes. Multiple imputation, multivariable linear regression, and age- and sex-stratified analyses were used to evaluate the association.
Official title: Cardiorespiratory Fitness and Mean Corrected Intraocular Pressure: A Cross-Sectional Study in a Normotensive Health Check-up Population
Key Details
Gender
All
Age Range
18 Years - 69 Years
Study Type
OBSERVATIONAL
Enrollment
2921
Start Date
2025-07-01
Completion Date
2026-03-01
Last Updated
2026-06-30
Healthy Volunteers
Yes
Conditions
Interventions
Mean corrected intraocular pressure (IOP) of both eyes
Intraocular pressure (IOP) was measured in both eyes using a non-contact tonometer (CT-1P, Topcon Corporation, Tokyo, Japan). The corrected IOP was automatically calculated by the device's built-in algorithm based on central corneal thickness. In Chinese healthy adults, corneal thickness is significantly associated with sex and age, which has important clinical implications for the correction of IOP measurements. To minimize the influence of diurnal fluctuation on IOP measurements, all IOP assessments were uniformly scheduled between 7:30 AM and 11:00 AM. Two measurements were taken for each eye and the average was recorded. The mean corrected IOP, defined as the average of the corrected IOP values of both eyes, was used as the primary outcome measure in this study.
Locations (1)
Sichuan Provinvial People's HSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital（ SAMS&SPPH，Affiliated Hospital of UESTC）ospital
Chengdu, Sichuan, China