Clinical Research Directory

You may be able to join if you: * Are 18 years or older * Have vision of 20/200 or better in at least one eye * Have watery eyes (epiphora) bad enough to need wiping or dabbing at least twice a day * Have watering caused by a functional/idiopathic, gustatory ("crocodile tears"), environmentally triggered (reflex), or obstructive cause - in one or both eyes * Have a healthy eye surface, with no significant dry eye, active eye infection, or active eye inflammation * Have adequate eyelid position and tone, where surgery is not the main treatment needed and reducing tear production is likely to help * Are willing and able to put drops in your eye(s) once each night for 7 days and attend the study visits * Can understand and follow the study procedures and communicate with study staff (an interpreter is allowed) You will not be able to join if you: * Have significant dry eye disease * Have had an active eye infection within the past 30 days * Have an active tear-sac infection, or a blocked tear duct that needs urgent surgery (a blocked tear duct that does not need surgery is allowed) * Currently use eye drops that affect tear production or eye-surface testing, unless you are willing to stop them for the study * Are allergic to, or should not take, atropine, similar (anticholinergic) medicines, or any ingredient in the study drops * Have narrow-angle or angle-closure glaucoma, where dilating the pupil would not be safe for you * Are pregnant or breastfeeding * Are taking part in another interventional study, or took part in one within 30 days before screening * Have any condition that, in the doctor's judgment, would make it unsafe for you to join or hard to follow the study