Clinical Research Directory

Browse clinical research sites, groups, and studies.

Sites Groups Studies

Back to Studies

ENROLLING BY INVITATION

NCT07678047

Leveraging Project ECHO for Improved Cervical Cancer Screening in Ethiopia

Sponsor: Albert Einstein College of Medicine

View on ClinicalTrials.gov

Summary

Project TICHILALECH ("she can" in Amharic), a five-year, implementation science study, is focused on improving cervical cancer screening, triage, and treatment and integration with human immunodeficiency virus (HIV) care at five Ethiopian hospitals, with a focus on human papillomavirus (HPV) self-collection as the recommended screening strategy for people living with HIV (PLHIV). To improve implementation of screening and treatment, Project ECHO (Extension for Community Healthcare Outcomes), a peer-based, virtual, knowledge sharing model, will be used to convene healthcare providers and stakeholders over a period of approximately three years (2026-2029). A customized curriculum is developed featuring didactic lectures, case-based presentations, and experience sharing for peer-mentoring. A pre/post study design will measure changes in delivery of clinical services, such as the proportion of HPV-positive patients that are appropriately triaged and treated, before and after each hospital's participation in the TICHILALECH ECHO intervention.

Official title: Leveraging Project ECHO for Improved Cervical Cancer Screening in Ethiopia: An Implementation Study of Integrated HPV Selfsampling in HIV Care Centers

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

Start Date

2026-06-24

Completion Date

2029-07

Last Updated

2026-07-01

Healthy Volunteers

Yes

Conditions

Cervical Carcinoma Human Papilloma Virus (HPV)

Interventions

BEHAVIORAL

TICHILALECH ECHO

TICHILALECH ECHO, the study intervention, is a provider training and peer-mentoring intervention that will be delivered through 1-hour virtual sessions with multidisciplinary teams of cervical cancer screening stakeholders, organized in modules with sessions delivered at a regular cadence across three years. Project ECHO sessions will address challenges to improving the screen-triage-treat cascade of care identified by a situational assessment, however, the study will not directly intervene on the screen-triage-treat cascade. Participants will present case studies from their practice for input and guidance from other participants.

Inclusion Criteria for Project ECHO and associated surveys, interviews, and focus group discussions: * 18 years or older * Willingness and ability to provide informed consent and participate in virtual, peer-mentoring through Project ECHO * Profession: Healthcare provider, any education/training/cadre with experience relevant to the delivery of cervical cancer screening and treatment or HIV care (e.g., cervical cancer screening, gynecologist, gynecological oncologist, or HIV/ ART provider), or other stakeholder (e.g., personnel at laboratories or health bureaus, administrators, ART data clerks) * Can communicate in English or Amharic (national language of Ethiopia) * Able and willing to meaningfully contribute in the virtual, peer-learning community of Project ECHO Inclusion criteria for end service users (PLHIV) for focus group discussion and routine clinical service delivery data: * 25 years or older (in accordance with Ethiopia's national cervical cancer screening guidelines for PLHIV) * Have been diagnosed with HIV * Have a history of cervical cancer screening that was performed at one of the five study sites, either during the course of our study or previously * Were screened with primary HPV DNA testing during the course of the study intervention period * Are eligible for cervical cancer screening in accordance with Ethiopia's national cervical cancer screening guidelines (e.g., have an intact cervix) Exclusion criteria for end service users (PLHIV) for focus group discussion: * HIV negative status * Age under 25 years * Any physical or mental disability that prevents the individual from consenting to cervical cancer screening and/or study participation * Patients without an intact cervix (e.g. a history of hysterectomy) * Anyone ineligible for cervical cancer screening in accordance with Ethiopia's national cervical cancer screening guidelines Note: Routine clinical service delivery data of PLHIV will be reviewed to determine intervention effect of providers participating in Project ECHO. PLHIV are not considered participants of the trial and are not consented.

Locations (1)

Addis Ababa University

Addis Ababa, Ethiopia