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COMPLETED
NCT07678385
PHASE4

Intraoperative Intravenous Lidocaine for Pain After Laparoscopic Appendectomy

Sponsor: Hospital Universitario de Caracas

View on ClinicalTrials.gov

Summary

This randomized, double-blind, placebo-controlled clinical trial evaluated whether intraoperative intravenous lidocaine infusion improves postoperative analgesia and recovery in patients undergoing laparoscopic appendectomy. The primary objective was to assess postoperative pain intensity and opioid consumption. Secondary outcomes included postoperative nausea and vomiting, time to bowel function recovery, length of hospital stay, plasma lidocaine concentrations, and adverse events.

Official title: Intraoperative Intravenous Lidocaine Infusion for Postoperative Analgesia and Recovery After Laparoscopic Appendectomy: A Randomized, Double-blind, Placebo-controlled Trial

Key Details

Gender

All

Age Range

18 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

225

Start Date

2024-02-01

Completion Date

2025-01-01

Last Updated

2026-07-01

Healthy Volunteers

Yes

Interventions

DRUG

Lidocaine (drug)

Intravenous lidocaine administered as a bolus followed by continuous infusion during laparoscopic appendectomy according to the study protocol.

DRUG

Normal Saline Placebo Infusion

Intravenous isotonic saline administered using the same infusion schedule as the active treatment to maintain blinding.

Locations (1)

Hospital Universitario de Caracas

Caracas, Miranda, Venezuela