Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults
Sponsor: Sairam Parthasarathy
Summary
Researchers want to identify which treatments for obstructive sleep apnea (OSA) work best and are easiest for patients to use consistently. Eligible participants will be randomly assigned one of three OSA treatments: traditional PAP therapy, a dental device, or a combination of two FDA-approved medications (atomoxetine and oxybutynin) that are currently approved for other conditions. Over the course of one year, participants will attend two in-person visits and take part in four phone check-ins to complete surveys, report any side effects, and discuss how well they are following their assigned treatment.
Official title: Comparative Effectiveness of Positive Airway Pressure Therapy, Dental Device, and Atomoxetine-Oxybutynin for Sleep Apnea: the ADAPT-OSA Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2400
Start Date
2026-09-01
Completion Date
2032-05-01
Last Updated
2026-07-01
Healthy Volunteers
No
Conditions
Interventions
Positive airway pressure (PAP) therapy
Positive airway pressure delivered via a nasal or face mask while a patient sleeps to keep the airways open.
Sleep dental device
An oral appliance worn during sleep to move the lower jaw forward, which tightens soft tissues and widens the airway to prevent sleep apnea.
Atomoxetine-oxybutynin
The combination of two medications (atomoxetine-oxybutynin) can reduce obstructive sleep apnea by increasing upper airway muscle activity.
Locations (4)
Banner University Medical Center Tucson
Tucson, Arizona, United States
Stanford Medical Center
Palo Alto, California, United States
University of Miami Miller School of Medicine
Miami, Florida, United States
University of Maryland Medical Center
Baltimore, Maryland, United States