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Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to evaluate izalontamab brengitecan (iza-bren) combined with osimertinib in participants with previously untreated, locally advanced or metastatic EGFR-mutant NSCLC, compared to osimertinib alone or osimertinib combined with platinum-based chemotherapy
Official title: A Phase III, Randomized, Open-label Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy as First-Line Therapy in Patients With EGFR-Mutant Locally Advanced or Metastatic Non-small Cell Lung Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
850
Start Date
2026-09-30
Completion Date
2031-12-30
Last Updated
2026-07-02
Healthy Volunteers
No
Conditions
Interventions
Iza-bren
Specified dose on specified days
Osimertinib
Specified dose on days
Pemetrexed
Specified dose on specified days
Carboplatin
Specified dose on specified days
Cisplatin
Specified dose on specified days
Locations (180)
Local Institution - 0212
Beverly Hills, California, United States
Local Institution - 0504
Fullerton, California, United States
Local Institution - 0357
La Jolla, California, United States
Local Institution - 0520
Pueblo, Colorado, United States
Local Institution - 0366
Orlando, Florida, United States
Local Institution - 0519
Palm Bay, Florida, United States
Local Institution - 0210
Honolulu, Hawaii, United States
Local Institution - 0207
Ottawa, Illinois, United States
Local Institution - 0503
Baltimore, Maryland, United States
Local Institution - 0523
Silver Spring, Maryland, United States
Local Institution - 0521
Edina, Minnesota, United States
Local Institution - 0364
Saint Paul, Minnesota, United States
Local Institution - 0403
St Louis, Missouri, United States
Local Institution - 0402
Omaha, Nebraska, United States
Local Institution - 0290
Lebanon, New Hampshire, United States
Local Institution - 0183
New Brunswick, New Jersey, United States
Local Institution - 0153
New York, New York, United States
Local Institution - 0157
The Bronx, New York, United States
Local Institution - 0385
Charlotte, North Carolina, United States
Local Institution - 0438
Sandusky, Ohio, United States
Local Institution - 0404
Portland, Oregon, United States
Local Institution - 0487
Easton, Pennsylvania, United States
Local Institution - 0200
Sioux Falls, South Dakota, United States
Local Institution - 0199
Memphis, Tennessee, United States
Local Institution - 0522
Beaumont, Texas, United States
Local Institution - 0525
Dallas, Texas, United States
Local Institution - 0529
San Antonio, Texas, United States
Local Institution - 0411
Salt Lake City, Utah, United States
Local Institution - 0165
Fairfax, Virginia, United States
Local Institution - 0530
Fairfax, Virginia, United States
Local Institution - 0528
Winchester, Virginia, United States
Local Institution - 0283
Seattle, Washington, United States
Local Institution - 0502
Morgantown, West Virginia, United States
Local Institution - 0424
Camperdown, New South Wales, Australia
Local Institution - 0439
Westmead, New South Wales, Australia
Local Institution - 0511
Greenslopes, Queensland, Australia
Local Institution - 0492
Adelaide, South Australia, Australia
Local Institution - 0447
Clayton, Victoria, Australia
Local Institution - 0437
Murdoch, Western Australia, Australia
Local Institution - 0059
Edmonton, Alberta, Canada
Local Institution - 0494
Abbotsford British Columbia, British Columbia, Canada
Local Institution - 0056
Vancouver, British Columbia, Canada
Local Institution - 0533
Oakville, Ontario, Canada
Local Institution - 0043
Oshawa, Ontario, Canada
Local Institution - 0012
Toronto, Ontario, Canada
Local Institution - 0045
Toronto, Ontario, Canada
Local Institution - 0407
Laval, Quebec, Canada
Local Institution - 0058
Montreal, Quebec, Canada
Local Institution - 0057
Montreal, Quebec, Canada
Local Institution - 0040
Regina, Saskatchewan, Canada
Local Institution - 0517
Beijing, Beijing Municipality, China
Local Institution - 0458
Beijing, Beijing Municipality, China
Local Institution - 0470
Chongqing, Chongqing Municipality, China
Local Institution - 0493
Fuzhou, Fujian, China
Local Institution - 0457
Fuzhou, Fujian, China
Local Institution - 0326
Dongguan Shi, Guangdong, China
Local Institution - 0331
Guangzhou, Guangdong, China
Local Institution - 0478
Zhongshan, Guangdong, China
Local Institution - 0321
Guilin, Guangxi, China
Local Institution - 0328
Nanning, Guangxi, China
Local Institution - 0330
Haikou, Hainan, China
Local Institution - 0343
Harbin, Heilongjiang, China
Local Institution - 0341
Weihui Shi, Henan, China
Local Institution - 0480
Zhengzhou, Henan, China
Local Institution - 0423
Zhengzhou, Henan, China
Local Institution - 0483
Jingzhou, Hubei, China
Local Institution - 0450
Wuhan, Hubei, China
Local Institution - 0482
Changsha, Hunan, China
Local Institution - 0467
Changsha Shi, Hunan, China
Local Institution - 0306
Changsha Shi, Hunan, China
Local Institution - 0347
Nanjing, Jiangsu, China
Local Institution - 0332
Shenyang, Liaoning, China
Local Institution - 0464
Xi'an, Shaanxi, China
Local Institution - 0479
Binzhou, Shandong, China
Local Institution - 0469
Weifang Shi, Shandong, China
Local Institution - 0319
Shanghai Shi, Shanghai Municipality, China
Local Institution - 0316
Taiyuan, Shanxi, China
Local Institution - 0463
Taiyuan, Shanxi, China
Local Institution - 0456
Chengdu, Sichuan, China
Local Institution - 0471
Chengdu, Sichuan, China
Local Institution - 0320
Dazhou Shi, Sichuan, China
Local Institution - 0472
Yibin, Sichuan, China
Local Institution - 0452
Tianjin, Tianjin Municipality, China
Local Institution - 0312
Hangzhou, Zhejiang, China
Local Institution - 0074
Marseille, Bouches-Du-Rhône, France
Local Institution - 0063
Dijon, Côte-D'Or, France
Local Institution - 0075
Nantes, Loire Atlantique, France
Local Institution - 0064
La Tronche, Nan, France
Local Institution - 0116
Lyon, Nan, France
Local Institution - 0109
Paris, Nan, France
Local Institution - 0062
Bron, Rhône, France
Local Institution - 0069
Villejuif, Val-De-Marne, France
Local Institution - 0073
Brest, France
Local Institution - 0066
Caen, France
Local Institution - 0070
Toulouse, France
Local Institution - 0071
Paris, Île-de-France Region, France
Local Institution - 0112
Gerlingen, Baden-Wurttemberg, Germany
Local Institution - 0111
Ulm, Baden-Wurttemberg, Germany
Local Institution - 0110
Wangen, Baden-Wurttemberg, Germany
Local Institution - 0001
Munich, Bavaria, Germany
Local Institution - 0105
Regensburg, Bavaria, Germany
Local Institution - 0446
Frankfurt am Main, Hesse, Germany
Local Institution - 0106
Oldenburg, Lower Saxony, Germany
Local Institution - 0100
Cologne, North Rhine-Westphalia, Germany
Local Institution - 0243
Dortmund, North Rhine-Westphalia, Germany
Local Institution - 0104
Essen, North Rhine-Westphalia, Germany
Local Institution - 0117
Hemer, North Rhine-Westphalia, Germany
Local Institution - 0101
Münster, North Rhine-Westphalia, Germany
Local Institution - 0103
Dresden, Saxony, Germany
Local Institution - 0412
Leipzig, Saxony, Germany
Local Institution - 0108
Großhansdorf, Schleswig-Holstein, Germany
Local Institution - 0239
Lübeck, Schleswig-Holstein, Germany
Local Institution - 0445
Giessen, Germany
Local Institution - 0225
Vadodara, Gujarat, India
Local Institution - 0444
Badsa, Haryana, India
Local Institution - 0337
Gurgaon, Haryana, India
Local Institution - 0436
Belagavi, Karnataka, India
Local Institution - 0215
Pune, Maharashtra, India
Local Institution - 0233
Mohali, Punjab, India
Local Institution - 0222
Chennai, Tamil Nadu, India
Local Institution - 0236
Meldola, Forli-Cesena, Italy
Local Institution - 0094
Candiolo, Turin, Italy
Local Institution - 0093
Bergamo, Italy
Local Institution - 0289
Brescia, Italy
Local Institution - 0089
Milan, Italy
Local Institution - 0087
Milan, Italy
Local Institution - 0238
Milan, Italy
Local Institution - 0091
Pavia, Italy
Local Institution - 0088
Verona, Italy
Local Institution - 0262
Nagoya, Aichi-ken, Japan
Local Institution - 0128
Toon-Shi, Ehime, Japan
Local Institution - 0136
Kurume-Shi, Fukuoka, Japan
Local Institution - 0121
Yokohama, Kanagawa, Japan
Local Institution - 0122
Sendai, Miyagi, Japan
Local Institution - 0433
Okayama, Okayama-ken, Japan
Local Institution - 0125
Hirakata-Shi, Osaka, Japan
Local Institution - 0129
Osakasayama-Shi, Osaka, Japan
Local Institution - 0141
Hamamatsu, Shizuoka, Japan
Local Institution - 0137
Chūōku, Tokyo-To, Japan
Local Institution - 0414
Kōtoku, Tokyo-To, Japan
Local Institution - 0138
Buk-Gu, Daegu, South Korea
Local Institution - 0506
Dalseo, Daegu, South Korea
Local Institution - 0127
Goyang-si, Gyeonggi-do, South Korea
Local Institution - 0133
Seongnam-si, Gyeonggi-do, South Korea
Local Institution - 0134
Hwasun-Gun, Jeollanam-do, South Korea
Local Institution - 0140
Cheongju-si, North Chungcheong, South Korea
Local Institution - 0124
Seocho -Gu, Seoul, South Korea
Local Institution - 0123
Songpa-Gu, Seoul, South Korea
Local Institution - 0139
Gyeongsangnam-do, South Korea
Local Institution - 0135
Seoul, South Korea
Local Institution - 0131
Seoul, South Korea
Local Institution - 0126
Seoul, South Korea
Local Institution - 0143
Majadahonda, Madrid, Spain
Local Institution - 0147
Seville, Seville, Spain
Local Institution - 0242
A Coruña, Spain
Local Institution - 0144
Jaén, Spain
Local Institution - 0226
Jaén, Spain
Local Institution - 0149
Jerez de la Frontera, Spain
Local Institution - 0148
Madrid, Spain
Local Institution - 0150
Málaga, Spain
Local Institution - 0241
Valencia, Spain
Local Institution - 0229
Kaohsiung City, Kaohsiung, Taiwan
Local Institution - 0230
New Taipei City, New Taipei, Taiwan
Local Institution - 0216
Taipei, Taichung, Taiwan
Local Institution - 0227
Gaoxiongka, Taiwan, Taiwan
Local Institution - 0221
Taoyuan City, Taoyuan, Taiwan
Local Institution - 0418
Taichung, Taiwan
Local Institution - 0420
Tainan, Taiwan
Local Institution - 0419
Taipei, Taiwan
Local Institution - 0021
Sur, Diyarbakır, Turkey (Türkiye)
Local Institution - 0265
Pendik, Istanbul, Turkey (Türkiye)
Local Institution - 0014
Adana, Turkey (Türkiye)
Local Institution - 0019
Adana, Turkey (Türkiye)
Local Institution - 0008
Ankara, Turkey (Türkiye)
Local Institution - 0003
Ankara, Turkey (Türkiye)
Local Institution - 0015
Antalya, Turkey (Türkiye)
Local Institution - 0041
Istanbul, Turkey (Türkiye)
Local Institution - 0039
Istanbul, Turkey (Türkiye)
Local Institution - 0050
Izmir, Turkey (Türkiye)
Local Institution - 0037
Izmir, Turkey (Türkiye)