Clinical Research Directory

ANTthracycline-induced Inflammation and OXidative Stress: 10-year Follow-up

Sponsor: University of Chile

Summary

The goal of this observational study is to learn about the long-term effects of anthracycline chemotherapy on inflammation, oxidative stress, and heart function in adult women with breast cancer. The main questions it aims to answer are: 1. Do inflammatory cytokine levels change after anthracycline chemotherapy and remain altered many years after treatment? 2. Are long-term markers of oxidative stress and antioxidant capacity associated with changes in heart structure or function after anthracycline exposure? This study does not include a comparison group. All participants were previously treated with anthracycline-based chemotherapy as part of their standard cancer care. Participants will: 1. Provide blood samples for the measurement of inflammatory cytokines and oxidative stress-related biomarkers 2. Undergo a clinical cardiovascular evaluation 3. Receive a transthoracic echocardiogram to assess heart function, including measures of systolic and diastolic function and myocardial deformation 4. Participate in a long-term follow-up assessment approximately 10 years after their initial cancer treatment

Official title: Long-Term Effects of Anthracycline Chemotherapy on Inflammatory Cytokines, Redox Status, and Ventricular Function in Breast Cancer Survivors

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