Clinical Research Directory

Inclusion Criteria: * Age ≥21 years at the time of consent. * Best corrected visual acuity between 24 and 73 ETDRS letters (approximately Snellen equivalent 20/32 to 20/300) in the study eye. * Diagnosis of chronic CSCR, defined as the presence of persistent SRF for ≥3 months, with or without secondary MNV. * Presence of pachychoroid features, including pachyvessels on ultra-widefield imaging in at least one quadrant and SFCT ≥300 µm. * Presence of intraretinal fluid and/or subretinal fluid involving the fovea, as confirmed by OCT. * Disease duration criteria: * CSCR without secondary MNV: persistent subretinal fluid for ≥3 months despite observation, or * CSCR with secondary MNV: presence of exudative fluid of any duration, with neovascularization confirmed on OCTA. * Ability and willingness to provide written informed consent. * Women of childbearing potential must have a negative pregnancy test prior to enrollment and agree to use a reliable form of contraception for the duration of the study. Exclusion Criteria: * Presence of ocular inflammation or primary choroidal disorders. * Presence of polypoidal choroidal vasculopathy (PCV). * Any ocular condition that, in the opinion of the investigator, could affect intra- or subretinal fluid or significantly alter visual acuity during the study (e.g., diabetic macular edema, retinal vein occlusion, uveitis, neovascular glaucoma). * Clinically significant cataract likely to reduce visual acuity by more than three ETDRS lines (i.e., worse than approximately 20/40 if the eye were otherwise normal). * Any intraocular surgery within 3 months prior to enrollment. * Prior treatment in the study eye with: * Intravitreal corticosteroids (any time), * Anti-VEGF therapy within 6 months, or * Photodynamic therapy (any time). * History of retinal detachment or surgery for retinal detachment, prior vitrectomy, or presence of a full-thickness macular hole. * Evidence of vitreomacular traction that may preclude resolution of macular edema. * Extensive intra- or subretinal hemorrhage exceeding 4 disc areas. * Aphakia in the study eye. * Pregnancy or breastfeeding. * Any medical, psychiatric, or systemic condition that, in the opinion of the investigator, would make study participation unsafe or interfere with study assessments.