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Oxidized Regenerated Cellulose and Voice Quality After Total Thyroidectomy
Sponsor: Ankara University
Summary
This randomized controlled trial evaluated whether placement of oxidized regenerated cellulose (ORC) over the recurrent laryngeal nerves during total thyroidectomy affects early postoperative voice quality. Patients undergoing bilateral total thyroidectomy for benign or malignant thyroid disease were assigned in a 1:1 ratio to bilateral placement of ORC within the thyroid bed or to conventional hemostasis without ORC. All participants underwent preoperative videolaryngostroboscopic examination and objective acoustic voice analysis. Acoustic assessment was repeated on postoperative day 21. The study evaluated changes in jitter, shimmer, normalized noise energy, harmonics-to-noise ratio, maximum phonation time, and the s/z ratio. Postoperative complications and adverse events potentially related to ORC were also recorded.
Official title: Effect of Oxidized Regenerated Cellulose on Voice Quality After Total Thyroidectomy: A Prospective Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2014-01-01
Completion Date
2014-08-31
Last Updated
2026-07-02
Healthy Volunteers
No
Interventions
Oxidized Regenerated Cellulose
A sterile, absorbable topical hemostatic material. A 1 × 2 cm piece was placed bilaterally over the recurrent laryngeal nerves within the thyroid bed after conventional hemostasis had been achieved.
Locations (1)
Ankara University School of Medicine, Ibn-i Sina Hospital
Ankara, Ankara, Turkey (Türkiye)