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Etiologic Diagnosis Algorithm in Infective Endocarditis
Sponsor: I.M. Sechenov First Moscow State Medical University
Summary
The goal of this study is to evaluate the impact of a diagnostic algorithm combining culture-based and molecular methods on the frequency of etiotropic antibiotic therapy prescription within 14 days of diagnosis of infective endocarditis
Official title: Development and Validation of An Algorithm of Etiological Diagnosis of Infective Endocarditis in Adults: An Open-Label Multicenter Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
128
Start Date
2026-01-20
Completion Date
2027-02-20
Last Updated
2026-07-02
Healthy Volunteers
No
Conditions
Interventions
Molecular tests (PCR, sequencing)
PCR and PCR with consequent sequencing of the blood (or tissue) will be performed in addition to the cultural methods in the experimental study arm
Standard Clinical Practice
Patients receive standard care with analysis of microorganisms in at least 2 or more separate blood culture sets and from cardiac tissue (if surgical treatment is performed); molecular test results are blinded for the treating physician
Locations (3)
A.N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of Health
Moscow, Russia
City Clinical Hospital Named After S. S. Yudin
Moscow, Russia
City Clinical Hospital №67 Named After L. A. Vorokhobova
Moscow, Russia