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Low Dose Bolus Ketamine For Use In Sickle Cell Pain Crisis
Sponsor: University of Mississippi Medical Center
Summary
The goal of this study is to learn if Ketamine works more efficiently, as compared to Opioids, for Sickle Cell Pain The main questions it aims to answer are: Does Ketamine lower the number of times participants need to be admitted for continued pain control during a Sickle Cell Pain Crisis. Does Ketamine decrease the amount of time it takes to reach adequate pain control/pain score improvement, as compared to Opioids. Patients could have too low or too high blood pressure or sleepiness. Researchers will compare Ketamine to Opioids (Morphine or Dilaudid) to see if Ketamine works to treat pain enough that you do not need to be admitted to the hospital. Participants will: On arrival to the Children's ER for Sickle Cell Pain crisis will get Ketamine, instead of Morphine or Dilaudid, along with the typical Tylenol, Toradol, Lidocaine patch for pain control while in the ER. During this time we will follow your reported pain scale (0-10) to monitor your pain response to the Ketamine, as well as follow rate of hospital admission.
Official title: Evaluation of a Standardized Low-Dose Bolus Ketamine Pathway for Management of Pediatric Sickle Cell Patients Presenting to the Emergency Department With Pain
Key Details
Gender
All
Age Range
2 Years - 21 Years
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2026-08-01
Completion Date
2029-10-01
Last Updated
2026-07-06
Healthy Volunteers
No
Interventions
Standardized Low-dose bolus IV Ketamine within 30 minutes of arrival and every 1 hour as needed for max of 3 doses.
This dosing is based off of Ideal body weight of each patient and dosed at 0.3 mg/kg/dose.
Standard Care (in control arm)
Standard Care in Historical Control Group
Locations (1)
University of Mississippi Medical Center, Pediatric Emergency Department
Jackson, Mississippi, United States