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Adjunctive Oral Probiotics in Endodontic Retreatment: Effects on Postoperative Pain and RANKL/OPG Levels
Sponsor: Ain Shams University
Summary
This study aimed to evaluate the effect of oral administration of probiotics as an adjunctive treatment to local intracanal medicaments, namely propolis and calcium hydroxide or empty canal, on the levels of receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG), as well as on postoperative pain following root canal retreatment of teeth with chronic apical periodontitis
Official title: The Effect of Systemic Administration of Probiotics and Intra-Canal Medications on Level of Nuclear Factor Kappa B Ligand, Osteoprotegerin and Postoperative Pain in Patients With Chronic Apical Periodontitis: (Randomized Controlled Clinical Trial)
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
72
Start Date
2025-10-04
Completion Date
2026-06-20
Last Updated
2026-07-06
Healthy Volunteers
No
Conditions
Interventions
Linex Adult®
Linex Adult® is an oral probiotic formulation containing Lactobacillus acidophilus, Bifidobacterium animalis, It is administered as one capsule once daily for 21 days.
Ca(OH)2 as intracanal medicament
Intracanal medication kept for 21 days
Placebo
Placebo capsule for 21 days
propolis intracanal medication
Intracanal medication kept for 21 days
Empty canal
Empty canal for 21 days
Locations (1)
Faculty of Dentistry, Ain Shams University
Cairo, Cairo Governorate, Egypt