Clinical Research Directory
Browse clinical research sites, groups, and studies.
Effect of Varicocelectomy on Spermatogenic Cell Count and Semen Parameters
Sponsor: Assiut University
Summary
This study aims to evaluate how varicocele surgery (varicocelectomy) affects the number of immature sperm cells (spermatogenic cells) found in the semen of infertile men. Varicocele, an abnormal dilation of veins in the scrotum, is a common cause of male infertility that can negatively impact semen quality and overall testicular function. While surgery is widely performed to improve standard semen parameters, this study specifically investigates its impact on the shedding of immature germ cells into the seminal fluid, which can be an indicator of impaired sperm production. Researchers will enroll 40 infertile married men, aged 20 to 45, who have been diagnosed with a clinical varicocele and exhibit abnormal semen parameters. All participants will undergo a single surgical intervention known as a subinguinal microsurgical varicocelectomy. To measure the effects of the surgery, participants will undergo careful semen analysis before the procedure, and again at 3 and 6 months postoperatively. The primary goal is to track changes in the spermatogenic cell count and abnormal sperm morphology, and to explore how these changes correlate with conventional semen parameters like sperm concentration, motility, and vitality.
Official title: Seminal Spermatogenic Cell Count Pre and Post Varicocelectomy: Relation to Seminal Parameters
Key Details
Gender
MALE
Age Range
20 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-08
Completion Date
2027-09
Last Updated
2026-07-06
Healthy Volunteers
No
Interventions
Subinguinal Microsurgical Varicocelectomy
A 3-4 cm subinguinal incision will be made below the external ring. Under 5-10X microscopic magnification, the internal spermatic artery will be identified and preserved. The internal spermatic veins and cremasteric veins, with the exception of vasal veins, will be ligated. The testicular arteries, cremasteric arteries, cremaster muscle fibers, nerves, lymphatic vessels, and vas deferens will be preserved before the spermatic cord is returned and the incision is closed.