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RECRUITING
NCT07685808
PHASE2

Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes

Sponsor: Regeneron Pharmaceuticals

View on ClinicalTrials.gov

Summary

This study will test an experimental drug called olatorepatide ("study drug") to determine how safe and effective this drug is compared to placebo and how easily the body can accept this drug at different doses and dosing schedules without causing side effects, as well as how the drug is processed in the body by participants with overweight or obesity but do not have diabetes. The study is looking at: * What side effects the study drug might cause * How much study drug is in the blood at different times * How well the study drug works * What effects the study drug may have on the body at different dosing schedules * If the body makes antibodies to the study drug as this may cause the study drug to not work as well

Official title: A Phase 2, Randomized, Placebo-Controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of Olatorepatide, a GLP-1/GIP Receptor Agonist, With Different Doses and Drug-Titration Algorithms in Participants Living With Overweight or Obesity

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

360

Start Date

2026-07-28

Completion Date

2028-01-21

Last Updated

2026-08-20

Healthy Volunteers

No

Interventions

DRUG

Olatorepatide

Administered per the protocol

DRUG

Placebo

Administered per the protocol

Locations (5)

Diablo Clinical Research - Flourish Research

Walnut Creek, California, United States

K2 Medical Research Maitland LLC, Main Office

Maitland, Florida, United States

Charter Research LLC - The Villages

The Villages, Florida, United States

Clinical Site Partners, LLC DBA Flourish Research

Winter Park, Florida, United States

AMR Clinical - Lexington

Lexington, Kentucky, United States