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MIRACLE-T2D Montelukast Intervention for Renal, Cardiovascular and Eye Health in Type 2 Diabetes
Sponsor: University of Colorado, Denver
Summary
Diabetes mellitus type 2 is associated with significant morbidity and mortality; and identifying new treatments for diabetes complications to be used alone or in combination with other therapies is a high priority. Hyperglycemia triggers proinflammatory pathways leading to damage in the kidneys, eyes and blood vessels; thus targeting proinflammatory lipid mediators called leukotrienes may represent a promising therapy for diabetes complications. This clinical trial seeks to investigate whether montelukast, a leukotriene antagonist, improves kidney, eye and vascular function in adult participants with type 2 diabetes and kidney disease.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2026-09-01
Completion Date
2031-08-31
Last Updated
2026-07-06
Healthy Volunteers
No
Interventions
Montelukast
10 my by mouth daily
Placebo
One capsule by mouth daily
Locations (1)
University of Colorado Denver
Aurora, Colorado, United States