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Precision Management of Urinary Tract Symptoms in Older Women
Sponsor: Megan Bradley
Summary
This project aims to improve the diagnosis and management of urinary tract symptoms in older women by comparing three common treatment strategies-empiric antibiotics, urinalysis-guided therapy, and culture-directed care-in a randomized trial. By integrating patient-reported outcomes, laboratory data, the study will identify which patients benefit from antibiotics and which can safely avoid them. Findings will inform precision care strategies and promote antibiotic stewardship while improving symptom outcomes and quality of life in this high-risk population.
Official title: Precision Management of Urinary Tract Symptoms in Older Women: A Randomized Trial to Reduce Overtreatment
Key Details
Gender
FEMALE
Age Range
65 Years - Any
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2026-07-14
Completion Date
2027-02-14
Last Updated
2026-07-07
Healthy Volunteers
No
Conditions
Interventions
Antibiotics
Participants will be provided either nitrofurantoin 100 mg oral twice a day for 5 days, trimethoprim/sulfamethoxazole 875/125 oral twice a day for 3 days, fosfomycin 3g once oral, ciprofloxacin 250 mg oral twice a day for 5 days or cephalexin 500 mg oral twice a day for 5 days
Locations (1)
UPMC-Magee Womens Hospital
Pittsburgh, Pennsylvania, United States