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Oral Microbiota and Muscle Function in the Ageing Subject
Sponsor: University Hospital, Rouen
Summary
Ageing of the general population may be a risk factor for various complications, including sarcopenia. Sarcopenia is a progressive loss of muscle mass and muscle strength, leading to a decrease in functional capacities. It affects between 0.7% and 16% of European adults over 70 years of age (1). Recent studies suggest that the faecal microbiota may be altered with ageing but also according to sarcopenic status. Furthermore, no study has currently published data on the relationship between salivary microbiota and sarcopenic status. The main hypothesis of this study is that a decrease in salivary microbiota richness could be associated with impaired handgrip strength in the ageing subject.
Official title: Oral Microbiota and Muscle Function in the Ageing Subject: MYOBIOTA Study
Key Details
Gender
All
Age Range
70 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-07
Completion Date
2028-07
Last Updated
2026-07-07
Healthy Volunteers
Yes
Interventions
Salivary and fecal microbiota sampling and muscle strength assessment
Collection of saliva and stool samples for microbiota analysis and assessment of handgrip strength in adults aged over 70 years.
Locations (1)
Rouen University Hospital
Rouen, France