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The Antiemetic Effects of Increased Splanchnic Perfusion, Induced by the Gut Hormone GIP, in Healthy Individuals
Sponsor: University of Copenhagen
Summary
This study investigates whether the gut hormone glucose-dependent insulinotropic polypeptide (GIP) can reduce feelings of nausea. GIP is naturally released after meals and is administered intravenously to healthy participants during the experiment. Nausea is induced using either glucagon-like peptide 1 (GLP-1), another gut hormone, or apomorphine, a medication known to trigger nausea. By combining these substances, the study aims to determine whether GIP can alleviate nausea. The findings may improve understanding of interactions between the gut and the brain.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
14
Start Date
2026-05-19
Completion Date
2027-04-28
Last Updated
2026-07-07
Healthy Volunteers
Yes
Conditions
Interventions
Glucose-dependent Insulinotropic Polypeptide (GIP)
GIP - gut hormone
GLP-1 (7-36) amide
gut hormone - GLP-1(7-36)NH2
Apomorphine Injectable Solution
used as a tool to induce nausea
Saline (0.9% NaCl)
Placebo
Locations (1)
Center for Clinical Metabolic Research, Herlev-Gentofte Hospital
Hellerup, Denmark