Clinical Research Directory

Inclusion Criteria: 1. Aged over 18 years 2. With no known allergies 3. Receiving invasive mechanical ventilator support 4. With a negative endotracheal aspirate culture on the day of ICU admission 5. Within the first 24 hours of mechanical ventilator support 6. Patients whose relatives agreed to participate in the study Exclusion Criteria: 1. Patients with positive endotracheal aspirate cultures within the first 48 hours of intensive care admission, 2. Patients undergoing radiotherapy or chemotherapy, 3. Patients with contraindications for oral care, 4. Patients with a platelet count below 30,000/mm³, 5. Patients who cannot be positioned appropriately, 6. Patients with agitation severe enough to prevent the procedure from being performed