Timing of Thromboprophylaxis After Postpartum Hemorrhage

COMPLETED

NCT07689136

Sponsor: University Tunis El Manar

Summary

Postpartum hemorrhage is a leading cause of maternal morbidity and mortality worldwide. Women who experience severe postpartum hemorrhage are at increased risk of both recurrent bleeding and venous thromboembolism. The optimal timing for starting pharmacological thromboprophylaxis after postpartum hemorrhage remains uncertain. This retrospective observational cohort study was conducted at the Center of Maternity and Neonatology of Tunis, Tunisia. The study included women who experienced postpartum hemorrhage between 2018 and 2024 and received pharmacological thromboprophylaxis during the postpartum period. The objective was to evaluate the association between the timing of thromboprophylaxis initiation and the occurrence of thromboembolic and hemorrhagic complications. The findings are expected to contribute to the optimization of thromboprophylaxis timing after postpartum hemorrhage and to improve the balance between the prevention of venous thromboembolism and the risk of recurrent bleeding.

Official title: Impact of the Timing of Pharmacological Thromboprophylaxis on Thromboembolic and Hemorrhagic Complications Following Postpartum Hemorrhage: A Retrospective Cohort Study

Key Details

Gender

FEMALE

Age Range

Any - Any

Study Type

OBSERVATIONAL

Enrollment

236

Start Date

2025-03-01

Completion Date

2025-03-30

Last Updated

2026-07-08

Healthy Volunteers

No

Conditions

Postpartum Hemorrhage Venous Thromboembolism Pulmonary Embolism Deep Vein Thrombosis

Interventions

DRUG

Pharmacologic Thromboprophylaxis

Pharmacologic thromboprophylaxis administered as part of routine postpartum clinical care after postpartum hemorrhage. Patients received either low molecular weight heparin (LMWH) or unfractionated heparin (UFH) according to the treating physician's clinical judgment and institutional practice. The study did not assign the intervention; it retrospectively evaluated the association between the timing of thromboprophylaxis initiation (≤24 hours versus \>24 hours after delivery) and the occurrence of thromboembolic and hemorrhagic complications.

Locations (1)

Center of Maternity and Neonatology of Tunis (CMNT)

Tunis, Tunisia

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