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Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label
Sponsor: Medical University of South Carolina
Summary
Smell dysfunction significantly impacts quality of life and safety, with limited effective treatments. This open-label study evaluates the preliminary efficacy of combining non-invasive trigeminal nerve stimulation (TNS) with standard smell training (ST) to improve olfactory function. Participants will complete 8 weeks of at-home treatment and attend three in-person visits for assessment. Improvements in smell, mood, sleep, and quality of life will be measured.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-07-10
Completion Date
2028-06-30
Last Updated
2026-08-12
Healthy Volunteers
No
Conditions
Interventions
Trigeminal Nerve Stimulation-enhanced Smell Training
TNS is a form of cranial nerve stimulation that uses a simple transcutaneous electrical nerve stimulation device, and adhesive electrodes that are attached to forehead to deliver low-level electrical current. Stimulating the trigeminal nerve activates the trigeminal afferent sensory pathway and central brain regions where the intranasal trigeminal and olfactory circuits converge. Smell Training requires 4 odors to be smelled individually for 10 sec each and record ratings.
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States