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The Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation in Individuals With Tiletamine Use Disorder
Sponsor: Shanghai Mental Health Center
Summary
Participants diagnosed with tiletamine use disorder will be assigned to active or sham taVNS for 5 days. Clinical outcomes ( e.g., behavioral paradigms measures and clinical scales ) and physiological markers (e.g., EEG and ECG) will be evaluated at baseline, post-treatment, and 3-month follow-ups to determine therapeutic efficacy and mechanisms of action.
Official title: Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Patients With Tiletamine Use Disorder: A Randomized Double-Blind Sham-Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-07-01
Completion Date
2028-01-01
Last Updated
2026-07-08
Healthy Volunteers
No
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation
The stimulation duration is 40 minutes per session, administered four times daily for 5 consecutive days (20 sessions in total).
Sham Stimulation
Identical device appearance and parameters, with minimal sensory stimulation and no vagal activation. The treatment schedule is identical to that of the active group.
Locations (1)
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China