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Effect of Knee Position on Muscle Loss During Leg Immobilization
Sponsor: Wageningen University
Summary
This study looks at what happens to leg muscles when the knee is kept straight or bent during five days of wearing a brace. We want to find out if keeping the knee bent (so the thigh muscle is stretched) helps prevent muscle loss compared to keeping the knee straight. Thirty healthy adults will take part. They will wear a knee brace for five days and have several tests before and after, including scans, blood samples, and small muscle samples. The results may help doctors find better ways to protect muscles when people cannot move, for example after surgery or illness.
Official title: A Novel Angle: Manipulating Knee Position to Understand Muscle Deterioration During Leg Immobilization
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-08-01
Completion Date
2028-06-01
Last Updated
2026-07-08
Healthy Volunteers
Yes
Interventions
Knee immobilization brace (0°) for 5 days
Unilateral knee immobilization at 0° flexion for 5 days using a brace; post-immobilization metabolic testing with tracer infusions and biopsies
Knee immobilization brace (60°) for 5 days
Unilateral knee immobilization at 60° flexion for 5 days using a brace; post-immobilization metabolic testing with tracer infusions and biopsies