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Theta Burst Transcranial Focused Ultrasound as a Novel Treatment for Cervical Dystonia
Sponsor: Robert Chen
Summary
This study is a single-blinded, randomized control study that aims to recruit 48 participants. Participants will be "randomized" into one of the study arms of the study: active stimulation to GPi, active stimulation to DN, or sham stimulation. The purpose of the study is to look into the effects of LIFUS in patients with cervical dystonia. The participation will include seven study visits, at least 24 hours apart. All study visits will take place at TWH. The first visit is a screening visit. Visits 2-6 will be on consecutive days. Visit 7 will be a week from Visit 6 or from your last day of LIFUS, whichever comes first.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
48
Start Date
2024-11-18
Completion Date
2029-12
Last Updated
2026-07-08
Healthy Volunteers
No
Conditions
Interventions
LIFUS - GPi Active
Bilateral thetaburst LIFUS stimulation to the globus pallidus
LIFUS - DN Active
Bilateral thetaburst LIFUS stimulation to dentate nucleus
LIFUS - Sham
Bilateral sham (placebo) LIFUS stimulation
Locations (1)
Toronto Western Hospital
Toronto, Ontario, Canada