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TG-INSIGHT With Joint POCUS, Hemostatic Potential in Patients With Severe Hemophilia A on Novel Replacement and Substitution FVIII Therapies
Sponsor: University of Texas Southwestern Medical Center
Summary
This is an observational research study to find out if there is a difference in the way children with moderate or severe hemophilia A, treated on two different types of factor replacement, form a clot and also evaluate if they develop tiny bleeds within the joint and subsequently early joint changes when receiving extended half-life factor VIII.
Official title: Hemostatic Potential in Patients With Severe Hemophilia A on Novel Replacement and Substitution FVIII Therapies (TG-INSIGHT With Joint POCUS)
Key Details
Gender
All
Age Range
6 Months - Any
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2026-07-22
Completion Date
2033-05
Last Updated
2026-09-29
Healthy Volunteers
No
Conditions
Interventions
Half-life factor VIII based replacement therapy
Children with moderate or severe hemophilia A being treated with prophylactic extended half-life factor VIII based replacement therapy (such as Altuviiio) as part of their hemophilia treatment to prevent spontaneous joint bleeds.
Non-FVIII based replacement therapy
Children with moderate or severe hemophilia A being treated with non-FVIII based replacement therapy (such as Hemlibra) as part of their hemophilia treatment to prevent spontaneous joint bleeds.
Locations (1)
The University of Texas Southwestern Medical Center
Dallas, Texas, United States