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High-Flow Nasal Cannula Versus Nasal CPAP as Primary Support in Preterm Respiratory Distress Syndrome
Sponsor: Kayseri City Hospital
Summary
This single-center randomized controlled trial compared heated humidified high-flow nasal cannula (HHHFNC) with nasal continuous positive airway pressure (nCPAP) as primary noninvasive respiratory support in preterm infants (gestational age 28-34 weeks; birth weight 1000-2000 g) with moderate respiratory distress syndrome. The primary outcome was treatment failure requiring invasive mechanical ventilation within the first 7 days.
Official title: Heated Humidified High-Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure as Primary Respiratory Support in Preterm Infants With Respiratory Distress Syndrome: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
28 Weeks - 34 Weeks
Study Type
INTERVENTIONAL
Enrollment
86
Start Date
2020-06-01
Completion Date
2022-05-01
Last Updated
2026-07-09
Healthy Volunteers
No
Interventions
Group 1 Heated humidified high-flow nasal cannula (HHHFNC)
HHHFNC delivered via the Vapotherm Precision Flow Hi-VNI system; initial flow 5 L/min (range 5-8 L/min), 37°C, 100% humidity; FiO2 titrated to maintain SpO2 91-95%.
Group 2 Nasal continuous positive airway pressure (nCPAP)
nCPAP delivered via a ventilator-driven system; pressure 5-8 cmH2O; FiO2 titrated to maintain SpO2 91-95%.
Locations (1)
Kayseri City Hospital
Kayseri, Kayseri, Turkey (Türkiye)