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Collagenase Injection for Contracture Management
Sponsor: The University of Texas Health Science Center, Houston
Summary
The overall goal is to investigate the effectiveness of a novel intervention - Collagenase injection, for contracture management in patients with neurological impairments, such as stroke, brain injury, and spinal cord injury.
Official title: Collagenase Injection for Contracture and Spasticity Management
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2026-09-01
Completion Date
2031-09-30
Last Updated
2026-07-09
Healthy Volunteers
No
Conditions
Interventions
Active XIAFLEX Collagenase injection
Collagenase is an enzyme that breaks down collagen, which is a key component of connective tissue, such as fascia. XIAFLEX is an FDA-Approved collagenase for treatment of Dupuytren's contracture with a palpable cord in the fingers, and Peyronie's disease in the penile tissue. In this research project, we plan to use collagenase to treat contracture in patients with neurological impairments, such as stroke, brain injury, and spinal cord injury. FDA guidelines will be followed for dosing and patient selection to minimize or reduce the risks.
Locations (1)
The University of Texas Health Science Center at Houston
Houston, Texas, United States