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Intraperitoneal Dexmedetomidine Versus Magnesium as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy
Sponsor: Alexandria University
Summary
Although both dexmedetomidine and magnesium sulphate have been individually evaluated as adjuvants to local anesthetics, direct comparisons between the two agents in intraperitoneal instillation during laparoscopic cholecystectomy remain limited. Understanding their relative efficacy and safety could provide valuable guidance for optimizing perioperative analgesia in these patients.
Official title: Intraperitoneal Instillation of Dexmedetomidine Versus Magnesium Sulphate as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-05-03
Completion Date
2027-01-01
Last Updated
2026-07-09
Healthy Volunteers
No
Interventions
Bupivacaine 100 mg + dexmedetomidine 1 µg/kg
20 ml bupivacaine + 1 µg/kg dexmedetomidine . The total volume will be adjusted to 50 mL with saline.
Bupivacaine 100 mg + magnesium sulphate 50 mg/kg
20 ml bupivacaine + 50 mg/kg magnesium sulphate . The total volume will be adjusted to 50 mL with saline.
Locations (1)
Alexandria University
Alexandria, Egypt