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Efficacy of 1% Nanochitosan Solution in the Treatment of Denture Stomatitis
Sponsor: Kerman University of Medical Sciences
Summary
The purpose of this study is to evaluate and compare the clinical efficacy of a 1% nanochitosan solution versus a standard Nystatin oral suspension in patients diagnosed with Newton's type II denture stomatitis (chronic atrophic candidiasis). Chitosan nanoparticles are investigated as a potential biocompatible, mucoadhesive alternative to traditional antifungal treatments to accelerate mucosal healing and reduce the erythema of the palatal mucosa.
Official title: Evaluation of the Efficacy of 1% Nanochitosan Solution Compared to Nystatin Oral Suspension in the Treatment of Newton's Type II Denture Stomatitis: A Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2016-01-17
Completion Date
2016-05-04
Last Updated
2026-07-13
Healthy Volunteers
No
Interventions
1% Nanochitosan Solution
A novel topical formulation of chitosan nanoparticles synthesized from low-molecular-weight chitosan using the ionic gelation method, prepared as a 1 wt.% aqueous solution.
Nystatin Oral Suspension
Standard commercial Nystatin oral suspension (100,000 U/mL) manufactured by Jaber Ebne Hayyan Pharmaceutical Company, utilized as the reference active control.
Locations (1)
Faculty of Dentistry, Kerman University of Medical Sciences
Kerman, Kerman, Iran