Clinical Research Directory

Inclusion Criteria: * Adults (≥18 years) diagnosed with peri-implantitis according to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions (Berglundh et al., 2018). * Implants presenting bleeding on probing (BoP) and/or suppuration on probing (SoP), increased probing depth, and progressive bone loss compared with previous records. When previous records are unavailable, implants will be included if they present bleeding and/or suppuration on gentle probing, probing depth ≥6 mm, and a bone level ≥3 mm apical to the most coronal portion of the rough implant surface. \- For patients requiring multiple peri-implantitis surgeries, only the first surgical intervention will be included. Exclusion Criteria: * Patients who, following non-surgical peri-implantitis treatment, present ≤1 site with isolated bleeding on probing, no suppuration on probing, probing depths ≤5 mm, and no progressive bone loss compared with pretreatment bone levels. * Contraindications to surgical peri-implantitis treatment, including plaque index \>20% and bleeding on probing \>10%. * Previous radiotherapy to the head and neck region. * Uncontrolled diabetes mellitus/hyperglycaemia (HbA1c \>7%). * Pregnancy or breastfeeding at the time of enrollment. * Alcohol or substance abuse. * Previous surgical treatment of peri-implantitis at the same implant. * Inability to complete the postoperative pain assessment (VAS) or the oral health-related quality of life (OHRQoL) questionnaires.