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RECRUITING
NCT07695233
NA

Pedunculopontine Nucleus Transcranial Ultrasound Stimulation as a Treatment of Freezing of Gait in Parkinson's Disease

Sponsor: Robert Chen

View on ClinicalTrials.gov

Summary

This study is investigating the use of transcranial ultrasound stimulation (TUS) on the Pedunculopontine nucleus (PPN) in changing freezing of gait in people with Parkinson's disease. The PPN is noted to be involved in voluntary movements, locomotion, and muscle tone. This will be assessed by patient-reported outcomes and analyzing the gait. The study will also investigate the effects of the stimulation on the PPN and surrounding connectivity by using magnetic resonance imaging (MRI).

Key Details

Gender

All

Age Range

18 Years - 90 Years

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2024-05-17

Completion Date

2028-12

Last Updated

2026-07-10

Healthy Volunteers

Yes

Interventions

DEVICE

Excitatory Stimulation

Excitatory Stimulation to the PPN

DEVICE

Inhibitory Stimulation

Inhibitory Stimulation to the PPN

DEVICE

Sham

Sham stimulation to PPN

Locations (1)

Toronto Western Hospital

Toronto, Ontario, Canada