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Pedunculopontine Nucleus Transcranial Ultrasound Stimulation as a Treatment of Freezing of Gait in Parkinson's Disease
Sponsor: Robert Chen
Summary
This study is investigating the use of transcranial ultrasound stimulation (TUS) on the Pedunculopontine nucleus (PPN) in changing freezing of gait in people with Parkinson's disease. The PPN is noted to be involved in voluntary movements, locomotion, and muscle tone. This will be assessed by patient-reported outcomes and analyzing the gait. The study will also investigate the effects of the stimulation on the PPN and surrounding connectivity by using magnetic resonance imaging (MRI).
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-05-17
Completion Date
2028-12
Last Updated
2026-07-10
Healthy Volunteers
Yes
Interventions
Excitatory Stimulation
Excitatory Stimulation to the PPN
Inhibitory Stimulation
Inhibitory Stimulation to the PPN
Sham
Sham stimulation to PPN
Locations (1)
Toronto Western Hospital
Toronto, Ontario, Canada