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Lemborexant Use for Cognition Improvement in Postoperative Delirium in Elderly Patients: A Randomized Controlled Trial
Sponsor: Beijing Tiantan Hospital
Summary
This prospective, randomized controlled trial aims to investigate the perioperative use of lemborexant, an orexin receptor antagonist, for reducing postoperative delirium (POD) in elderly patients undergoing general anesthesia.
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
992
Start Date
2026-09-01
Completion Date
2029-12-31
Last Updated
2026-07-10
Healthy Volunteers
No
Conditions
Interventions
Lemborexant Pill
The intervention group will take Lemborexant tablets four times during the perioperative period
Placebo tablet
The control group will take placebo tablets with the same appearance, smell and properties as the intervention group four times during the perioperative period