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Hippo-YAP Pathway and Related miRNAs in Preterm Birth
Sponsor: Cumhuriyet University
Summary
This completed observational study evaluated the expression of Hippo-YAP pathway-related genes and proteins and selected microRNAs in maternal blood, placental tissue, and myometrial tissue obtained from women who underwent cesarean delivery at term or preterm gestational ages. The study compared women with spontaneous preterm delivery and women with term delivery. Maternal blood, placental tissue, and myometrial tissue samples were analyzed using molecular, biochemical, and immunohistochemical methods to explore whether Hippo-YAP pathway activity and related miRNA expression patterns may be associated with the pathophysiology of preterm birth.
Official title: Analysis of Hippo-YAP Pathway Genes and Proteins and Related miRNA-195, miRNA-181c, miRNA-200a, and miRNA-375 Expression in Maternal Blood, Placental Tissue, and Myometrial Tissue From Women With Term and Preterm Cesarean Delivery
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
OBSERVATIONAL
Enrollment
44
Start Date
2021-06-01
Completion Date
2024-05-31
Last Updated
2026-07-10
Healthy Volunteers
No
Conditions
Interventions
Laboratory Biomarker Analysis
Laboratory analysis of maternal blood, placental tissue, and myometrial tissue samples for Hippo-YAP pathway-related gene, protein, and microRNA expression. No treatment or clinical intervention was assigned to participants.
Locations (1)
Sivas Cumhuriyet University Faculty of Medicine
Sivas, Kayseri Ave, Turkey (Türkiye)