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Efficacy of Nonsteroidal Anti-Inflammatory Drugs for the Prevention of Cystoid Macular Edema Following Cataract Phacoemulsification
Sponsor: Pomeranian Medical University Szczecin
Summary
This randomized clinical study evaluated the effectiveness of different postoperative nonsteroidal anti-inflammatory drug (NSAID) regimens in patients undergoing uncomplicated phacoemulsification cataract surgery. Eighty-eight eligible participants were randomly assigned to one of four treatment groups using a simple dice-based randomization procedure: bromfenac 0.09% twice daily for 2 weeks, bromfenac 0.09% twice daily for 4 weeks, diclofenac 0.1% four times daily for 4 weeks, or nepafenac 0.1% three times daily for 4 weeks. All patients received the same standard perioperative care and adjunctive dexamethasone treatment. The primary outcome was central subfield thickness (CST) measured by spectral-domain optical coherence tomography (OCT) at 6 and 12 weeks after surgery. Secondary outcomes included best-corrected distance visual acuity, refraction, and intraocular pressure.
Key Details
Gender
All
Age Range
30 Years - Any
Study Type
INTERVENTIONAL
Enrollment
88
Start Date
2020-10-14
Completion Date
2024-05-22
Last Updated
2026-07-10
Healthy Volunteers
No
Conditions
Interventions
Bromfenac 0.09 % Ophthalmic Solution
Bromfenac 0.09% ophthalmic solution administered twice daily for 2 weeks after cataract surgery.
Bromfenac 0.09 % Ophthalmic Solution
Bromfenac 0.09% ophthalmic solution administered twice daily for 4 weeks after cataract surgery.
Nepafenac 0.1% eyedrops
Nepafenac 0.1% ophthalmic solution administered three times daily for 4 weeks after cataract surgery.
diclofenac 0.1% ophthalmic susp.
Diclofenac 0.1% ophthalmic solution administered four times daily for 4 weeks after cataract surgery.
Locations (1)
University Clinical Hospital No. 2, Pomeranian Medical University in Szczecin
Szczecin, Poland