Clinical Research Directory

Inclusion Criteria: * Age from 18 to 45 years old. * Singleton Pregnancy * Gestational age between 24 and 34 weeks, confirmed by last menstrual period and/or first-trimester ultrasound. * Diagnosis of preterm labor, defined as Regular uterine contractions (≥4 in 20 minutes recorded in CTG) with a documented change in cervical dilation (e.g., from\<1 cm to ≥2 cm) or, in nulliparous women, a dilation of ≥2 cm * Intact membranes at the time of presentation. Exclusion Criteria: Established preterm labor (efficient uterine contractions 4/10mins each one lasts more than 40 Seconds recorded in CTG, with cervical changes (dilatation\>4cm, effacement\>80%)). * Evidence of chorioamnionitis or intrauterine infection. * Preterm premature rupture of membranes (PPROM). * Maternal medical disorders contraindicating tocolysis, such as severe preeclampsia, significant cardiac disease, or uncontrolled diabetes mellitus. * Contraindications to continuation of pregnancy, including placental abruption or placenta previa with bleeding. * Vaginal bleeding of unknown origin" as a specific exclusion criterion, as it may indicate abruption or other pathologies.