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Procalcitonin Versus Serum Zinc for Diagnosis of Ventilator-Associated Pneumonia in ICU Patients
Sponsor: Sohag University
Summary
Ventilator-associated pneumonia (VAP) is a common and serious infection among mechanically ventilated ICU patients. Early diagnosis remains challenging because clinical and radiological findings may lack specificity. Procalcitonin (PCT) is a well-established biomarker of bacterial infection, while serum zinc has recently emerged as a potential marker of immune dysfunction and infection severity. This prospective observational cohort study will compare the diagnostic accuracy of serum procalcitonin and serum zinc for the diagnosis of ventilator-associated pneumonia in 84 adult ICU patients. Diagnostic performance will be assessed using ROC curve analysis, sensitivity, specificity, positive predictive value, and negative predictive value. Associations between biomarker levels, inflammatory markers, disease severity scores, and clinical outcomes will also be evaluated.
Official title: Comparative Diagnostic Accuracy of Procalcitonin Versus Serum Zinc as Biomarkers for the Diagnosis of Ventilator Acquired Pneumonia in Adults Admitted to the ICU
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
84
Start Date
2026-07-07
Completion Date
2028-12
Last Updated
2026-07-10
Healthy Volunteers
No
Conditions
Interventions
Serum Procalcitonin Measurement
Measurement of serum procalcitonin levels for evaluation of diagnostic accuracy in ventilator-associated pneumonia.
Serum Zinc Measurement
Measurement of serum zinc levels for evaluation of diagnostic accuracy in ventilator-associated pneumonia.
Locations (1)
Sohag University Hospital
Sohag, Sohag Governorate, Egypt