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Adjunctive Antioxidant Effect of Centella Asiatica Nanoemulsion Gel in Management of Periodontitis
Sponsor: Mansoura University
Summary
The aims of the current study are: 1. Evaluation of the clinical efficacy of local delivery of nanoemulsion gel containing Centella asiatica extract as an adjunct to conventional non-surgical periodontal therapy in periodontitis patients. 2. Evaluation of the antioxidant effect of this treatment by the assessment of nuclear factor erythroid 2-related factor 2 (NrF2) and glutathione peroxidase 1 (GPX1) in the gingival crevicular fluid (GCF) samples.
Official title: Adjunctive Antioxidant Effect of Centella Asiatica Nanoemulsion Gel in the Management of Periodontitis
Key Details
Gender
All
Age Range
25 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2025-03-21
Completion Date
2025-09-08
Last Updated
2026-07-13
Healthy Volunteers
Yes
Interventions
Centella asiatica nanoemulsion gel
Following scaling and root planing, patients in Group 1 received local subgingival application of Centella asiatica nanoemulsion gel via disposable syringe with a blunt-ended cannula, applied once weekly for 3 months.
Scaling and Root Planing (SRP)
Full-mouth scaling and root planing using ultrasonic instrumentation and Gracey curettes, plus standardized oral hygiene instructions.
Locations (1)
faculty of dentistry Mansoura university, Mansoura, 35516
Al Mansurah, Egypt