Clinical Research Directory
Browse clinical research sites, groups, and studies.
Hyaluronidase for Sclerodactyly in Systemic Sclerosis Trial
Sponsor: Medical University of South Carolina
Summary
Translational studies have demonstrated reduced hyaluronidase activity in the skin of patients with systemic sclerosis. It is thought this may contribute to the progressive fibrosis seen in this disease. Several studies have demonstrated that exogenous hyaluronidase is very effective at improving systemic sclerosis associated microstomia. Therefore, this study aims to explore hyaluronidase for systemic sclerosis associated sclerodactyly.
Official title: Digital Intradermal Hyaluronidase for Sclerodactyly in Systemic Sclerosis
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2026-09-01
Completion Date
2027-11
Last Updated
2026-07-13
Healthy Volunteers
No
Conditions
Interventions
Hyaluronidase (Hylenex)
Patients will receive monthly injections of hyaluronidase into 1 finger on each hand over a 28 week treatment period.
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States