Clinical Research Directory

Inclusion Criteria: * Age 21 years - 55 years * Self-reported use of cigarettes within the past 30 days * Biochemical confirmation of cigarette use: o Carbon monoxide (CO) breath sample ≥10 ppm * Fagerström Test for Nicotine Dependence (FTND) score ≥5, indicating moderate to high nicotine dependence * Fluent in English * Willing to try an oral nicotine pouch * Willing to abstain from nicotine for at least 12 hours prior to each experimental session Exclusion Criteria: * Age younger than 21 years or older than 55 years * Biochemical evidence inconsistent with recent cigarette use: o CO breath sample \<10 ppm * Expressed intent to reduce or quit nicotine use within the next 30 days * History of medical conditions contraindicated for nicotine use (e.g., uncontrolled hypertension, recent cardiac events) * Primary use of non-cigarette products (e.g., cigars, pipe tobacco, smokeless tobacco) * Prior use of oral nicotine products in their lifetime