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RECRUITING
NCT07699159

Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions

Sponsor: Centre for Addiction and Mental Health

View on ClinicalTrials.gov

Summary

The Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (CALM) Master Observational Trial is a prospective, longitudinal observational study that seeks to improve clinical care for youth with multiple mental health conditions (MMHC), also known as mental health multimorbidity in the literature. MMHC is conceptualized as the presence of two or more mental health diagnoses under the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). MMHC is common in youth seeking mental health services and is associated with less favorable outcomes and greater health services utilization. Mental health disorders also accumulate in youth over time. The Master Observational Trial (MOT) will investigate MMHC in critical developmental periods in youth and identify risk and protective factors that will provide a mechanistic understanding of how MMHC develops over time. A subset of participants will also enroll in a Deep Phenotyping Cohort, which includes enhanced clinical and cognitive assessments and multimodal neuroimaging to investigate neurobiological mechanisms underlying MMHC and identify potential biomarkers of illness complexity and progression. In the near future, we aim to add to the current protocol to embed both a clinical trials network for youth mental health in Ontario and Calgary within the CALM study and add digital phenotyping using wearable technology to generate digital and physiological markers of MMHC. The current protocol focuses on establishing the longitudinal MOT cohort and Deep Phenotype Cohort only as a first step towards these long term CALM goals.

Official title: Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (CALM): A Master Observational Trial

Key Details

Gender

All

Age Range

11 Years - 24 Years

Study Type

OBSERVATIONAL

Enrollment

1620

Start Date

2025-03-04

Completion Date

2028-03-31

Last Updated

2026-07-13

Healthy Volunteers

No

Locations (6)

University of Calgary

Calgary, Alberta, Canada

McMaster Children's Hospital, Hamilton Health Sciences

Hamilton, Ontario, Canada

Children's Hospital of Eastern Ontario Research Institute

Ottawa, Ontario, Canada

The Royal Ottawa Mental Health Centre

Ottawa, Ontario, Canada

The Hospital for Sick Children

Toronto, Ontario, Canada

Centre for Addiction and Mental Health (CAMH)

Toronto, Ontario, Canada