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NCT07699718

Selective Median Lobe Surgery Outcomes Study

Sponsor: Necmettin Erbakan University

View on ClinicalTrials.gov

Summary

This prospective multicenter observational cohort study will evaluate clinical outcomes after selective median lobe transurethral surgery for benign prostatic obstruction. Eligible men with lower urinary tract symptoms or urinary retention who are scheduled for selective median lobe-only TURP, HoLEP, or anatomical endoscopic enucleation as part of routine clinical care will be enrolled and followed after surgery. The study will collect preoperative clinical data, symptom scores, uroflowmetry, postvoid residual volume, prostate volume, intravesical prostatic protrusion measurements, cystoscopic anatomical findings, intraoperative variables, and postoperative outcomes. The primary outcome is composite clinical failure at 12 months. The main aim is to identify practical preoperative urology-based anatomical and functional predictors of clinical failure after selective median lobe surgery and to develop an exploratory prediction model that may help improve patient selection in future practice.

Official title: UNVEIL-BPO Median Lobe Study: An International Multicenter Evaluation of Selective Median Lobe Resection and Enucleation

Key Details

Gender

MALE

Age Range

45 Years - Any

Study Type

OBSERVATIONAL

Enrollment

420

Start Date

2026-09-01

Completion Date

2030-12-01

Last Updated

2026-07-13

Healthy Volunteers

No

Interventions

PROCEDURE

Selective Median Lobe TURP

Selective transurethral resection of the median lobe or median component of the bladder outlet. The procedure is performed according to the treating surgeon's routine clinical practice and is not assigned by the study protocol.

PROCEDURE

Selective Median Lobe HoLEP/AEEP

Selective enucleation of the median lobe or median component of the bladder outlet using HoLEP or another anatomical endoscopic enucleation platform. The procedure is performed according to the treating surgeon's routine clinical practice and is not assigned by the study protocol.

Locations (2)

University of Health Sciences Türkiye, Van Training and Research Hospital

Van, Edremit, Turkey (Türkiye)

Necmettin Erbakan University, Meram Faculty of Medicine

Konya, Konya, Turkey (Türkiye)