Clinical Research Directory

Inclusion Criteria: The patients will be selected according to the following criteria: * Adults aged 35 to 50 years. * Presence of typical CTS symptoms for at least one month. * Cutoff values of VAS are defined between 35 mm and 64 mm. * Patients were diagnosed with moderate carpal tunnel syndrome clinically by physical examination (positive Phalen's test and Tinel's sign). and confirmed by an electrodiagnostic study (EDX) with a fractionated sensory nerve conduction velocity for the median nerve across the wrist of 40 m/s or less and with sensory distal latency more than 3.6 ms and less than 4 ms and a normal CMAP amplitude in the APB muscle. * Body mass index from 18.5 tobetween 18.5 and ability and willingness to provide informed consent and comply with the study protocol. Exclusion Criteria: \- Participants will be excluded if they meet any of the following criteria: * Severe carpal tunnel syndrome requires surgical intervention. * Presence of systemic diseases associated with CTS such as diabetes mellitus, rheumatoid arthritis, hypothyroidism, or other inflammatory disorders. * Pregnancy. * History of fractures, trauma, or surgery in the wrist or hand region. * Corticosteroid injection in the carpal tunnel within the previous 3 months. * Use of wrist splints or other CTS treatments in the last 3 months. * Presence of peripheral neuropathy or other neurological disorders affecting the upper limb. * Burns or skin lesions in the hand or forearm area. * Presence of pacemakers, metal implants, prostheses, or intrauterine devices (IUDs) that may interfere with electrotherapy modalities. * Peripheral vascular diseases affect the upper limb.