Clinical Research Directory

Inclusion Criteria: 1. Diagnosis of left-sided aldosterone-producing adrenal adenoma. 2. Unwillingness to undergo adrenalectomy or presence of contraindications to surgery. 3. Ability and willingness to provide written informed consent. Exclusion Criteria: 1. History of alcohol allergy. 2. Inability to discontinue beta-blockers. 3. Inability to discontinue anticoagulants, antiplatelet agents, or glucocorticoids. 4. Platelet count \<50 × 10\^9/L or uncorrectable coagulation dysfunction. 5. Imaging findings suggestive of adrenal cyst, adrenal hematoma, or myelolipoma. 6. Presence of other active malignancies. 7. Pregnancy or breastfeeding; alcohol abuse; drug abuse; or mental disorder that may interfere with study participation. 8. Severe comorbid conditions, including any of the following: New York Heart Association (NYHA) class III-IV heart failure or hospitalization for worsening chronic heart failure within the previous 3 months; stroke or acute coronary syndrome within the previous 3 months; severe anemia (hemoglobin \<60 g/L); severe hepatic disease (alanine aminotransferase ≥3 × the upper limit of normal); severe renal disease requiring dialysis or estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73 m²; systemic inflammatory response syndrome (SIRS); poorly controlled diabetes mellitus (fasting blood glucose ≥13.3 mmol/L); severe obesity (body mass index ≥35 kg/m²); untreated aneurysm; or any other severe medical condition that may interfere with treatment or study follow-up. 9. Poor compliance or any other condition that, in the investigator's judgment, would make the participant unsuitable for the study.