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Placental Progesterone Membrane Receptors in Fetal Growth Restriction
Sponsor: Samsun University
Summary
This prospective observational case-control study aims to compare placental expression levels of progesterone membrane receptors, including PGRMC1, PGRMC2, and PAQR family receptors, among pregnancies affected by impaired fetal growth and appropriately grown control pregnancies. Pregnancies with suspected impaired fetal growth were phenotypically classified before biomarker analyses according to the contemporary Delphi consensus and ISUOG diagnostic criteria into fetal growth restriction (FGR) and small for gestational age (SGA). Placental tissue samples obtained at delivery were analyzed using quantitative real-time polymerase chain reaction (qRT-PCR). The final study cohort comprised 110 singleton pregnancies, including 48 FGR, 29 SGA, and 33 appropriately grown controls. The study also evaluated the association between progesterone membrane receptor expression and adverse perinatal outcomes.
Official title: Expression of Progesterone Membrane Receptors in Placentas From Pregnancies Complicated by Intrauterine Growth Restriction: A Prospective Observational Case-Control Study
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
OBSERVATIONAL
Enrollment
110
Start Date
2025-08-01
Completion Date
2026-07-20
Last Updated
2026-08-07
Healthy Volunteers
Yes
Conditions
Locations (2)
Canan Soyer Çalışkan
Samsun, Turkey (Türkiye)
Samsun University Faculty of Medicine Samsun Training and Research Hospital
Samsun, Turkey (Türkiye)