Clinical Research Directory

Inclusion Criteria: * 18 years of age and older inclusive, at the time of signing the informed consent * Endoscopic bilateral NP score of at least 5 out of a maximum score of 8 (with a minimum score of 2 in each nasal cavity) assessed by the investigator * Participants who have had previous nasal surgery for the removal of nasal polyps, have used at least three consecutive days of systemic corticosteroids in the previous 2 years for the treatment of nasal polyps, or are medically unsuitable or intolerant to systemic corticosteroid * Participants presenting with severe nasal polyp symptoms defined as symptoms of nasal congestion/blockade/obstruction with moderate or severe severity and loss of smell or rhinorrhoea (runny nose) based on clinical assessment by the investigator * Presence of symptoms of chronic rhinosinusitis as described by at least 2 different symptoms for at least 12 weeks prior to Visit 1, one of which should be either nasal blockage/obstruction/congestion or nasal discharge (anterior/posterior nasal drip), or facial pain/pressure and/or reduction or loss of smell * Male or eligible female participants Exclusion Criteria: * As a result of medical interview, physical examination, or screening investigation the physician responsible considers the participant unfit for the study * Cystic fibrosis * Antrochoanal polyps * Nasal cavity tumor (malignant or benign) * Fungal rhinosinusitis * Severe nasal septal deviation occluding one nostril preventing full assessment of nasal polyps in both nostrils * Participants who had a sino-nasal or sinus surgery changing the lateral wall structure of the nose making impossible the evaluation of nasal polyp score * Acute sinusitis or URTI at screening or in 2 weeks prior to screening * Ongoing rhinitis medicamentosa (rebound or chemical induced rhinitis) * Participants who have had an asthma exacerbation requiring admission to hospital within 4 weeks of screening * Participants who have undergone any intranasal and/or sinus surgery (for example polypectomy, balloon dilatation or nasal stent insertion) within 6 months prior to Visit 1; nasal biopsy prior to Visit 1 for diagnostic purposes only is excepted. * Participants where NP surgery is contraindicated in the opinion of the Investigator * Participants with other conditions that could lead to elevated eosinophils such as hyper-eosinophilic syndromes including (but not limited to) Eosinophilic granulomatosis with polyangiitis (EGPA) (formerly known as Churg-Strauss Syndrome) or Eosinophilic Esophagitis * Participants with a known, pre-existing parasitic infestation within 6 months prior to Visit 1 * A known immunodeficiency (e.g., human immunodeficiency virus - HIV), other than that explained by the use of corticosteroids (CSs) taken as therapy for asthma * A current malignancy or previous history of cancer in remission for less than 12 months prior to screening.NOTE: Participants that had localised carcinoma of the skin which was resected for cure will not be excluded * Participants who have known, pre-existing, clinically significant cardiac, endocrine, autoimmune, metabolic, neurological, renal, gastrointestinal, hepatic, hematological or any other system abnormalities that are uncontrolled with standard treatment * Participants with current diagnosis of vasculitis. Participants with high clinical suspicion of vasculitis at screening will be evaluated and current vasculitis must be excluded prior to enrolment * Participants with allergy/intolerance to the excipients of depemokimab, a monoclonal antibody, or biologic * Participants that have been exposed to ionizing radiation in excess of 10 millisievert (mSv) above background over the previous 3-year period as a result of occupational exposure or previous participation in research studies * Participants using INCS (including intranasal liquid steroid wash/douching) for at least 8 weeks immediately prior to screening * Participants on inhaled corticosteroids exhalation through nose (Inhaled corticosteroids exhalation through nose \[ICS/ETN\]) method of administration for their asthma and NP for at least the 8 weeks immediately prior to screening * Participants who have received depemokimab (Exdensur), mepolizumab (Nucala), reslizumab (Cinqair/Cinqaero), or benralizumab (Fasenra) within 12 months prior to Visit 1 or experienced treatment failure with monoclonal antibodies targeting IL-5/5R * Participants who have received omalizumab (Xolair), dupilumab (Dupixent) or Tezpelumab (Tezpire) within 130 days prior to Visit 1 * Previously participated in any study with depemokimab, mepolizumab, reslizumab, or benralizumab and received study intervention (including placebo) within 12 months prior to Visit 1 * Women who are pregnant or lactating or are planning on becoming pregnant during the study * ALT \>2\* ULN * Total bilirubin \>1.5\* ULN; For participants with Gilbert's syndrome can be included with total bilirubin \>1.5\* ULN if direct bilirubin is \<=1.5\* ULN * Cirrhosis or current unstable liver or biliary disease per investigator assessment defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminemia, esophageal or gastric varices, persistent jaundice