Clinical Research Directory

Evaluation of Salivary Biomarkers in Individuals With Bruxism

Sponsor: Giresun University

Summary

The goal of this observational study is to evaluate salivary biomarkers and perceived stress in adults with bruxism compared with healthy individuals. The study aims to determine whether salivary cortisol, immunoglobulin A (IgA), free kappa light chain (FLC-κ), free lambda light chain (FLC-λ), total free light chains, and perceived stress levels differ between individuals with bruxism and healthy controls. The main questions it aims to answer are: * Do salivary cortisol, IgA, FLC-κ, FLC-λ, and total free light chain levels differ between individuals with bruxism and healthy controls? * Is perceived stress associated with changes in salivary biomarkers in individuals with bruxism? Researchers will compare participants with bruxism and healthy control participants to evaluate differences in salivary biomarker levels and perceived stress. Participants will: * undergo a clinical examination for the diagnosis of bruxism or confirmation of healthy status; * complete the Perceived Stress Scale (PSS-14) questionnaire; * provide an unstimulated saliva sample for laboratory analysis of cortisol, IgA, free kappa light chain, free lambda light chain, and total free light chains.

Official title: Salivary Biomarkers and Perceived Stress in Individuals With Bruxism: A Case-Control Study

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