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Efficacy of 5% Chitosan Nanoparticle Paste in the Treatment of Recurrent Aphthous Stomatitis
Sponsor: Kerman University of Medical Sciences
Summary
The purpose of this study is to evaluate the therapeutic clinical efficacy of a synthesized 5 wt.% chitosan nanoparticle paste compared to a standard topical corticosteroid (triamcinolone acetonide 0.1% oral paste) in patients suffering from minor recurrent aphthous stomatitis. The study specifically monitors changes in clinical ulcer diameter and pain reduction.
Official title: Wound Healing Effect of Chitosan Nanoparticles and Low Molecular Weight Chitosan: Animal and Clinical Studies
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2009-04-21
Completion Date
2009-12-01
Last Updated
2026-07-14
Healthy Volunteers
No
Conditions
Interventions
Triamcinolone Acetonide 0.1% Oral Paste
Standard reference topical corticosteroid ointment utilized as the active standard of care control.
5 wt.% Chitosan Nanoparticle Paste
Synthesized via ionic gelation method using low molecular weight chitosan and sodium tripolyphosphate, formulated into a 5 wt.% mucoadhesive paste.